Technologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs

Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid based formulations have shown the most commercial success and continue to be widely employed. Physicochemical characteristics of the drug and advantages and disadvantages of different technologies need to be considered before selecting a technology. Advances being made in solubility enhancement technologies and sophisticated analytical techniques to measure the performance of the dosage forms in-vitro and in-vivo and new research in the area of modeling and simulation are expected to facilitate the development of new dosage forms that will successfully overcome the limitations of not only poorly soluble drugs but also poorly permeable drugs.